Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is the leading cause of cancer death worldwide. Scientists from the National University of Singapore (NUS) have discovered a biomarker, called adenosine deaminase acting on RNA-1 (ADAR1), which has the potential to improve the diagnosis, prognosis and treatment of this disease.Led by Dr Polly Chen from the Cancer Science Institute of Singapore (CSI Singapore) at NUS, the team is also the first to demonstrate that the editing of protein-making sequences promotes the development of ESCC.
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