Prion protein can trigger spongiform encephalopathy and neurodegeneration

Transmissible spongiform encephalopathy or prion disease is triggered by the conversion from cellular prion protein to pathogenic prion protein. Notably, C-transmembrane form of prion protein and cytosolic prion protein can result in neurodegenerative diseases in cases of error location,aggregation tendency, failure of signal peptides, body stress or incomplete removal of topologic prion protein.