The malignant Hodgkin/Reed-Sternberg (RS) cell is embedded in a collagen-rich microenvironment. In this week's issue of Blood, Cader and colleagues elucidate a potentially important collagen-mediated signaling pathway supporting the survival of RS cells in Epstein-Barr virus-positive (EBV+) Hodgkin Disease (HD), demonstrating that expression of the EBV latent membrane protein-1 (LMP1) upregulates the expression of discoidin domain receptor 1 (DDR1), a collagen-activated receptor tyrosine kinase.
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