First topical pharmacologic therapy to enter clinical trials for "double chin"

Topokine Therapeutics has initiated dosing in a Phase 2, randomized controlled clinical trial of XAF5 Gel for reduction of excess submental fat, commonly known as "double chin." XAF5 Gel is a proprietary skin formulation of a compound already known to reduce fat around the human eye. Study participants are applying XAF5 Gel or placebo once a night to skin under the chin."Patients are increasingly interested in non-invasive therapies to rejuvenate the face," said Jeffrey S. Dover, MD, FRCPC, a nationally recognized dermatologist and member of the Topokine's Scientific Board of Advisors.