Stem cell-based approach manipulates brain cells, targets specific gene mutations causing dementia and ALS

Johns Hopkins scientists have developed new drugs that - at least in a laboratory dish - appear to halt the brain-destroying impact of a genetic mutation at work in some forms of two incurable diseases, amyotrophic lateral sclerosis (ALS) and dementia. They made the finding by using neurons they created from stem cells known as induced pluripotent stem cells (iPS cells), which are derived from the skin of people with ALS who have a gene mutation that interferes with the process of making proteins needed for normal neuron function...