Early onset breast cancer associated with mutations in novel tumor suppressor gene

An international team of scientists has identified an association between heritable, rare mutations in the RINT1 gene and increased risk of early onset breast cancer, according to research reported at the American Society of Human Genetics 2013 annual meeting in Boston. The rare mutations in RINT1, a tumor suppressor gene, were detected in three of 49 families participating in a study that sequenced the whole exome, the protein-coding DNA, of families with multiple individuals affected by breast cancer...