Wednesday, September 18, 2013

Autophagy and neurodegenerative disorders

Autophagy is a highly conserved process through the evolution of species, from eukaryotic microorganisms to humans. Bulky cytoplasmic contents, organisms (bacteria, viruses) and soluble proteins are degraded by autophagy and reused for the synthesis of new molecules. This process is generally induced by a change of environmental conditions, such as nutrient deprivation, oxidative stress and ultraviolet radiation. However, it has also been associated with normal procedures like development, differentiation and defence against pathogens...

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