Tuesday, August 27, 2013

What causes schizophrenia? Gene discoveries offer clues

Scientists have discovered 13 new locations in our genetic code that could help explain the cause of schizophrenia.


The researchers conducted an analysis over 59,000 people, publishing their findings in Nature Genetics. The study included 5,001 schizophrenia patients alongside 6,243 controls. This analysis was followed by a type of review that combines studies, a meta-analysis of studies into genome-wide associations.


They also replicated single nucleotide polymorphisms (SNPs) within 168 genomic regions of independent brain samples. SNPs are the most common type of genetic variation found within the human genome.


The study was done through a collaboration of researchers from the University of North Carolina School of Medicine, the Karolinska Institutet in Sweden, the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, and the Mt. Sinai School of Medicine in New York.


The results of the analysis identified 22 genome locations, with 13 new locations that they believe are involved in the development of schizophrenia.


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