A new experiment in mice suggests that a diet with below-normal calories could help the effectiveness of drug cancer treatment.
The team, led by Jean-Ehrland Ricci of the French Institute for Health and Medical Research in France, put mice who had developed lymphoma into two separate groups: those who ate a diet with caloric intake 25% lower than normal, and those who ate a regular diet.
After following these diets for 1 week, the mice were then divided into four groups for the next 10 days:
- Normal-diet mice who received an experimental cancer treatment
- Normal-diet mice who did not receive the drug
- Reduced-calorie diet mice given treatment
- Reduced-calorie diet mice not given cancer treatment.
The experimental treatment is dubbed ABT-737 - a targeted therapy designed to promote cancer cell death.
After these 10 days of the study, both the treatment and the calorie restriction ceased, at which point the mice resumed eating however much they wished.
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