Restless Legs Syndrome (RLS), a neurological disorder characterized by unpleasant sensations in the legs and the urge move them, affects up to 10% of Americans, although little is known about its cause. In a study published online in Genome Research, researchers have demonstrated a common genetic variant associated with RLS alters expression in a critical brain gene during fetal development. RLS is not caused by a single genetic defect, but rather is a complex disorder influenced by many genetic and environmental components, with age being the strongest risk factor.
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