First clinical study of new gene therapy shows promise for reducing motor symptoms of Parkinson's disease

A new triple gene therapy called ProSavin might safely improve motor function in Parkinson's patients by reprogramming brain cells to produce dopamine - a chemical essential for the proper control of movement - according to a phase 1/2 trial published in The Lancet. "Lack of dopamine results in the tremors, limb stiffness, and loss of balance that characterise Parkinson's", explains study leader Professor Stéphane Palfi from AP-HP, Groupe Henri-Mondor Albert-Chenevier in Créteil, France.