Next-generation whole exome sequencing sheds more light on Alzheimer's risk

A research team from The University of Nottingham has helped uncover a second rare genetic mutation which strongly increases the risk of Alzheimer's disease in later life.In an international collaboration, the University's Translational Cell Sciences Human Genetics research group has pinpointed a rare coding variation in the Phospholipase D3 (PLD3) gene which is more common in people with late-onset Alzheimer's than non-sufferers.The discovery is an important milestone on the road to early diagnosis of the disease and eventual improved treatment.